Doing the extraordinary
to restore the ordinary

We’re developing the first adaptive neuromodulation therapy that is able to treat women suffering with mixed urinary incontinence

Personalized Adaptive Pudendal Neuromodulation

Amber’s fully implantable PicostimTM System targets the pudendal nerve with a device that can both stimulate and sense physiological responses. The therapy is configurable to the individual’s need and able to respond dynamically to different events, adapting as needed between modes of operation.
Amber Therapeutics Picostim System

Mixed urinary incontinence (MUI) in need of a breakthrough

A global problem

Urinary incontinence is a debilitating and highly prevalent condition that significantly reduces the quality of life for millions of people globally.

Majority not receiving help

Symptoms of this condition are found in 40 million women in the US, and yet only 16 million are currently receiving therapy.

Ground-breaking advancement

While existing therapies focus on either urge incontinence (a sudden and intense need to void the bladder) or stress incontinence (urine leakage caused by activities such as jumping or coughing), Amber’s UI therapy represents a ground-breaking advancement as the first singular therapy capable of addressing mixed (both urge and stress) incontinence.

Restoring normal

Our mission at Amber is to transform the lives of women suffering from this condition by helping to restore their normal physiology

Promising Results from first in-human study (AURA-2)

The AURA-2 study recruited 13 women with either severe refractory urge urinary incontinence or mixed urinary incontinence and was conducted at the University Hospital Antwerp (Belgium).

The study fulfilled its primary aim of demonstrating safety and feasibility of Amber’s new surgical procedure, validating a scalable approach to accurately implant two electrode leads on the pudendal nerve.

The study demonstrated:

Clinical Efficacy

Strong evidence of pilot efficacy in both women with mixed urinary incontinence and severe refractory urge incontinence

Quality of Life

Clinically significant improvements in symptom-related quality-of-life

Advanced Functionality

The utility of patient-controlled adaptive algorithms using the IPG’s integrated sensors
ABOUT US

Amber Therapeutics

Amber Therapeutics was founded in 2021 by Aidan Crawley, Tim Denison, Stefan De Wachter and Charles Knowles with a mission to develop and deliver breakthrough neuromodulation therapies that can fundamentally transform outcomes in areas of unmet clinical need. We have since grown into a multidisciplinary team, combining deep medical device experience with a culture and mindset focused on transformational innovation. Amber UI is the company’s first therapy, aiming to restore normal physiological function in women suffering with mixed urinary incontinence.

Our Leadership

Aidan Crawley
Co-founder & CEO
Aidan founded the company from an Entrepreneur in Residence position at Oxford Science Enterprises in 2021. Aidan has substantial experience building early stage technology companies as both founder and executive. He was the first business hire and Head of Business Development at Addepar in the US, helping grow the company from $0-50m revenue and >$1bn valuation. Aidan began his career in finance, working for Goldman Sachs’ UK M&A team.
Tim Denison
Co-founder & Chief Engineer
Professor Denison is co-founder and the Chief Engineer of Amber Therapeutics, responsible for leading the company’s technical development and engineering effort. He also holds a joint appointment in Engineering Science and Clinical Neurosciences at Oxford, where he explores the fundamentals of physiologic closed-loop systems. Prior to that, Tim was a Technical Fellow at Medtronic PLC and Vice President of Research & Core Technology for the Restorative Therapies Group, where he helped oversee the design of next generation neural interface and algorithm technologies for the treatment of chronic neurological disease, developing critical sensors and algorithms for commercialized brain and spinal cord-based therapies. ⁠Over 1 million patients have a system with technology he designed. Tim received an A.B. in Physics from The University of Chicago, and an M.S. and Ph.D. in Electrical Engineering from MIT. He recently completed his MBA and was named a Wallman Scholar at The University of Chicago. In 2015, he was elected to the College of Fellows for the American Institute of Medical and Biological Engineering (AIMBE).
Stefan De Wachter
Co-founder & Chief Scientist
Professor De Wachter is co-founder and the Chief Scientist of Amber Therapeutics, responsible for therapy design and clinical innovation. Stefan holds a joint appointment as Head of Urology at Antwerp University Hospital and Professor of Urology at Antwerp University, Belgium. His main research interests address bladder and urethral neurophysiology with a particular focus on novel diagnostics and treatment of urinary dysfunction using neuromodulation approaches (> 200 peer reviewed publications). He is a world recognized innovator in the field of pelvic health and has been a significant contributor to almost all major pivotal trials relevant to advancing new treatments over the last 20 years. Stefan received an MD at Ghent University in 1999 and was awarded European Association of Urology “best thesis” for his PhD in 2004. He was certified as a Fellow of the European Board of Urology in 2012.
Charles Knowles
Co-founder & CMO
Professor Knowles is co-founder and the Chief Medical Officer of Amber Therapeutics, responsible for leading the company’s ambitious clinical trial portfolio. In addition to being a practicing surgeon, he holds several senior academic positions including Professor of Surgery at Queen Mary University of London, Professor of Experimental Therapeutics at University College London and Chief Academic Officer at the Cleveland Clinic London. His main research interests cover the development and evaluation of new technologies for the diagnosis and treatment of chronic bowel diseases (especially neuromodulation and cell therapies). Clinically, he is a key international opinion leader on pelvic floor disorders with a focus on incontinence. Charles qualified from the University of Cambridge and undertook general surgical training and a PhD in London. He became a Fellow of the Royal College of Surgeons in 1996 and was certified as a specialist colorectal surgeon in 2005. He was awarded an honorary fellowship of the American Society of Colon and Rectal Surgeons in 2021 reflecting his international contributions to research (> 300 peer reviewed publications), major general and colorectal surgical textbooks, guidance and policy documents.
Iain Anthony
VP Regulatory, Clinical, Quality
Iain is Amber’s Vice President of Regulatory, Clinical & Quality, joining with over 15 years experience in the medical device industry in both start-up companies and large multinationals. His experience covers class II and III implantables, including combination device drug products. Most recently Iain served as a board Director at RUA Life Sciences PLC with responsibility for Clinical, Regulatory and Quality. Prior to this he was Director of Pre-clinical and Clinical Regulatory Affairs at MedAlliance LLC following his role as Head of Clinical Affairs at Terumo Aortic. Iain has expertise in clinical trial design and clinical operations execution, including designing novel clinical trials for FDA submissions, and EU pre- and post-market trials. He has experience of both US and EU medical device regulatory affairs in addition to experience of implementing and developing ISO13485 Quality Management Systems. Iain has a PhD in Neurovirology and Neuropathology from the University of Edinburgh and has over 40 peer reviewed publications.
Tomás Furey
VP Operations
Tomás Furey is Vice President of Operations of Amber Therapeutics. Trained originally as a manufacturing engineer, Tomás has more than twenty five years of experience in medical device development and manufacturing. He began his career in medtech in process re-engineering at Boston Scientific. He has since held senior operational roles in Lake Region Medical, Vyaire Medical and Balt Medical. He has a particular interest in process excellence and the application of lean business techniques and has held several successful roles in operations management, quality and regulatory affairs.

Our Board of Directors

Aidan Crawley
Co-founder & CEO
Aidan founded the company from an Entrepreneur in Residence position at Oxford Science Enterprises in 2021. Aidan has substantial experience building early stage technology companies as both founder and executive. He was the first business hire and Head of Business Development at Addepar in the US, helping grow the company from $0-50m revenue and >$1bn valuation. Aidan began his career in finance, working for Goldman Sachs’ UK M&A team.
Tiffany Le
NEA
Tiffany joined NEA in 2020 and predominantly invests in Life Sciences, with a strong focus in medical devices, healthtech, and innovations at the intersection of technology and medicine. Previously, Tiffany held roles at Kaiser Permanente Ventures and L.E.K. Consulting. She has also collaborated on research leveraging brain organoid and synthetic biology models to interrogate Alzheimer’s disease. Tiffany received a BA in Business Economic Theory from UCLA and an MBA from Harvard Business School.
Liliane Chamas
OSE
Liliane joined Oxford Science Enterprises in December 2019, bringing over a decade of experience across genetics research and digital innovation in health systems. At OSE, Liliane focuses on uncovering early-stage ideas and building new businesses at the intersection of healthcare and technology. Previously, Liliane worked for the World Health Organization, evaluating technologies to improve access to care in indigenous and refugee communities, and co-ordinating global guidance for the use of digital health in diabetes, hypertension and smoking cessation. As a Global Health Policy Fellow at Imperial College London, she advised on the reform of undergraduate medical education in Myanmar. As Deputy Head of the NHS/Foreign Office joint unit for the UK Prosperity Fund, Liliane led on a global strategy to facilitate exchange of technology and healthcare best practices with countries in Latin America, Africa and Southeast Asia. Liliane completed her PhD in Human Genetics at the University of Oxford as a Canadian Rhodes Scholar.
Caroline Gaynor
Lightstone Ventures
Caroline Gaynor is a Partner of Lightstone Ventures and focuses on new investments in the biopharmaceutical and medical device sectors out of the firm’s Dublin office.. She currently serves as a board director for Catamaran Bio, Parvalis Therapeutics, ProVerum, Carrick Therapeutics and FIRE-1 and as board observer for Volta Medical and Cerevance. She also previously served on the board of ALX Oncology. She is a council member of the Irish Venture Capital Association and a member of the BioInnovate Ireland Board of advisors.
Kevin Chu
F-Prime Capital
Kevin Chu joined F-Prime Capital in 2014 and is currently a Principal on the healthcare investment team based in San Francisco. Prior to F-Prime, Kevin was an Associate Consultant with IMS Consulting Group in New York, where he advised biopharmaceutical clients on development and commercial strategy. At F-Prime, Kevin focuses primarily on investments in therapeutics, medical devices, and life science tools companies. He was a member of the founding team at Shinobi Therapeutics, led the fund’s investments in Cadence Neuroscience and Amber Therapeutics, and was involved with several legacy fund investments including Innovent Biologics (1801.HK), Semma Therapeutics (acquired by Vertex), Modis Therapeutics (acquired by Zogenix), Farapulse (acquired by Boston Scientific), Cytek Biosciences (NASDAQ: CTKB), and Sipai Health Technology (0314.HK). He also works closely with the Eight Roads Ventures China team to manage F-Prime’s healthcare investment efforts in China. Kevin holds a B.S.E. from the University of Pennsylvania where he studied Bioengineering and Engineering Entrepreneurship.
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